Van Huysse J W, Bealer S L
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.
Am J Physiol. 1992 Jun;262(6 Pt 2):R1064-9. doi: 10.1152/ajpregu.1992.262.6.R1064.
Electrolytic ablation of the periventricular tissue surrounding the anteroventral third cerebral ventricle (AV3V-X) results in immediate increases in norepinephrine release in the paraventricular hypothalamic nucleus/anterior hypothalamus (P/A) and in the dorsomedial medulla (DM) and depletion of norepinephrine and epinephrine throughout the brain. The present study determined whether catecholamine depletion and/or altered norepinephrine release persisted after recovery from the acute effects of AV3V-X. Fourteen to eighteen days after surgery, catecholamine concentrations throughout the brain and norepinephrine release in the P/A and DM during hemorrhage were measured in control-operated and AV3V-X rats. AV3V-X decreased epinephrine content only in the midbrain, increased norepinephrine only in the cortex, and produced no differences in central nervous system dopamine. Hemorrhage-induced norepinephrine release was significantly greater in the P/A of AV3V-X rats than in control animals, whereas norepinephrine release in the DM increased equally in both groups. Thus AV3V-X does not result in chronic global central nervous system catecholamine depletion and enhances norepinephrine release in the P/A during hemorrhage.
电解消融第三脑室前腹侧周围的脑室周围组织（AV3V-X）会导致下丘脑室旁核/下丘脑前部（P/A）和延髓背内侧（DM）中去甲肾上腺素释放立即增加，并且使全脑去甲肾上腺素和肾上腺素耗竭。本研究确定了在从AV3V-X的急性效应中恢复后，儿茶酚胺耗竭和/或去甲肾上腺素释放改变是否持续存在。在手术14至18天后，测量对照手术大鼠和接受AV3V-X手术的大鼠全脑的儿茶酚胺浓度以及出血期间P/A和DM中的去甲肾上腺素释放。AV3V-X仅使中脑的肾上腺素含量降低，仅使皮质中的去甲肾上腺素增加，并且在中枢神经系统多巴胺方面未产生差异。出血诱导的去甲肾上腺素释放在接受AV3V-X手术的大鼠的P/A中比对照动物显著更大，而两组中DM中的去甲肾上腺素释放均同等增加。因此，AV3V-X不会导致慢性全身性中枢神经系统儿茶酚胺耗竭，并且在出血期间增强P/A中的去甲肾上腺素释放。
