[声门鳞状细胞癌中S100标记的树突状细胞表达及其与预后的相关性]
[Expression of S100-labeled dendritic cells in glottic squamous cell carcinoma and its correlation to prognosis].
作者信息
Chen Wen-Kuan, Chen Fu-Jin, Zeng Zong-Yuan, Wu Guo-Hao, Guo Zhu-Ming, Wei Mao-Wen, Yang An-Kui, Zhang Quan, He Jie-Hua, Hou Jing-Hui
机构信息
Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P. R. China.
出版信息
Ai Zheng. 2005 Oct;24(10):1272-5.
BACKGROUND & OBJECTIVE: Dendritic cells (DCs) are the most important antigen-presenting cells, and can synthesize and secrete S100 protein. This study was designed to investigate the expression of S100-labeled DCs in glottic squamous cell carcinoma, and analyze its correlation to the prognosis.
METHODS
The expression of S100-labeled DCs in peritumoral tissues of 111 specimens of gllotic squamous cell carcinoma was detected by immunohistochemistry; 17 specimens of normal tissues were used as control. The correlation of S100-labeled DCs expression to prognosis of the 111 patients was evaluated.
RESULTS
The positive rates of S100-labeled DCs were 51.35% (57/111) in peritumoral tissues of gllotic squamous cell carcinoma, and 0 in normal tissues. The 5-year survival rate was significantly higher in S100-positive group than in S100-negative group (72.31% vs. 53.91%, P=0.030).
CONCLUSIONS
The glottic squamous cell carcinoma patients with obvious infiltration of S100-labeled DCs may achieve good prognosis.
背景与目的
树突状细胞（DCs）是最重要的抗原呈递细胞，能够合成并分泌S100蛋白。本研究旨在探讨声门鳞状细胞癌中S100标记的DCs的表达情况，并分析其与预后的相关性。
方法
采用免疫组织化学法检测111例声门鳞状细胞癌标本瘤周组织中S100标记的DCs的表达；以17例正常组织作为对照。评估111例患者中S100标记的DCs表达与预后的相关性。
结果
声门鳞状细胞癌瘤周组织中S100标记的DCs阳性率为51.35%（57/111），正常组织中为0。S100阳性组的5年生存率显著高于S100阴性组（72.31%对53.91%，P=0.030）。
结论
S100标记的DCs明显浸润的声门鳞状细胞癌患者可能预后良好。
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