Kikuchi Kentaro, Kusama Kaoru, Taguchi Kohei, Ishikawa Fumitaka, Okamoto Motoyoshi, Shimada Jun, Sakashita Hideaki, Yamamo Yoshiro
1st Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry, Sakado, Saitama, Japan.
Anticancer Res. 2002 Mar-Apr;22(2A):545-57.
Dendritic cells (DCs) are antigen-presenting cells that initiate and modulate immune responses, including tumor immunity. In this study we examined, immunohistochemically, the distribution of DC subsets in the primary tumor, adjacent tissue and regional lymph nodes (RLNs) of patients with oral squamous cell carcinoma (OSCC). The numbers of S100+ and CD1a+ DCs in tissue adjacent to the primary tumor were greater in patients without metastasis to RLNs (PN- cases), compared with those with metastasis (PN+ cases), while greater numbers of CD83+ DCs in the primary tumors were found in PN+ cases. In the RLNs, the numbers of S100+ and CD1a+ DCs were less in PN+ cases than in PN- cases, while the numbers of CD83+ DCs were greater in PN+ cases compared with those in PN- cases. These results suggest that the distribution of DC subsets in OSCC may reflect the degree of tumor immunity induced in the host bearing OSCC.
树突状细胞（DCs）是启动和调节免疫反应（包括肿瘤免疫）的抗原呈递细胞。在本研究中，我们采用免疫组织化学方法检测了口腔鳞状细胞癌（OSCC）患者原发性肿瘤、邻近组织及区域淋巴结（RLNs）中DC亚群的分布情况。与发生RLNs转移的患者（PN + 病例）相比，未发生RLNs转移的患者（PN - 病例）原发性肿瘤邻近组织中S100 + 和CD1a + DCs的数量更多，而在PN + 病例的原发性肿瘤中发现CD83 + DCs的数量更多。在RLNs中，PN + 病例的S100 + 和CD1a + DCs数量比PN - 病例少，而PN + 病例的CD83 + DCs数量比PN - 病例多。这些结果表明，OSCC中DC亚群的分布可能反映了荷OSCC宿主中诱导的肿瘤免疫程度。
