Ye Xue, Niu Yun, Fang Zhi-Yi
Breast Cancer Pathology Department & Research Laboratory, Cancer Hospital, Tianjin Medical University, Tianjin, P. R. China.
Ai Zheng. 2005 Oct;24(10):1290-2.
Genomic instability, including whole chromosome loss or gain, ploidy change, and a variety of chromosome aberration, is a characteristic of tumor cells. Centrosome abnormality is also found in several kinds of tumors. Abnormal centrosome can cause multipolar spindle formation, chromosome mis-segregation, and unequal distribution, and finally leads to cancers. Therefore, abnormal centrosome is common in tumor cells, and centrosome amplification is probably an early event in the origination and development of cancer.
基因组不稳定，包括整条染色体的丢失或增加、倍性改变以及各种染色体畸变，是肿瘤细胞的一个特征。在几种肿瘤中也发现了中心体异常。异常的中心体可导致多极纺锤体形成、染色体错误分离和不均等分配，最终导致癌症。因此，异常中心体在肿瘤细胞中很常见，中心体扩增可能是癌症发生和发展过程中的一个早期事件。
