Hansen Tom G
Odense Universitetshospital, Anaestesiologisk-intensiv Afdeling.
Ugeskr Laeger. 2005 Sep 26;167(39):3672-5.
Propofol infusion syndrome, characterised by cardiovascular collapse, metabolic acidosis, hepatomegaly, renal failure and rhabdomyolysis, is a rare and often fatal syndrome seen in critically ill children undergoing long-term propofol sedation. Propofol may impair mitochondrial free fatty acid metabolism, resulting in an imbalance between energy demand and utilisation and thus compromising cardiac and peripheral muscle cell function. Propofol should be used with caution for sedation in critically ill children, as well as for long-term anaesthesia in otherwise healthy children, and doses exceeding 4 mg/kg/h should be avoided.
丙泊酚输注综合征的特征为心血管衰竭、代谢性酸中毒、肝肿大、肾衰竭和横纹肌溶解，是在接受长期丙泊酚镇静的危重症儿童中出现的一种罕见且往往致命的综合征。丙泊酚可能会损害线粒体游离脂肪酸代谢，导致能量需求与利用之间失衡，从而损害心脏和外周肌肉细胞功能。丙泊酚在危重症儿童镇静以及健康儿童长期麻醉时应谨慎使用，应避免剂量超过4mg/（kg·h）。
