Vej-Hansen Anders, Nygaard Birte
Amtssygehuset i Herlev, Endokrinologisk Afdeling J106.
Ugeskr Laeger. 2005 Sep 26;167(39):3684-7.
Iodine uptake and the effect of radioiodine treatment of nontoxic goiter were investigated after the introduction of iodine to salt.
A retrospective study was done of 61 patients (48 women and 13 men with a median age of 56 (range 28-78)) with nontoxic goiter, examined by 24-hour radioiodine uptake. 42 of the patients were treated with radioiodine (median 600 MBq, range 200-600 MBq). The results were compared with those from a study done 10 years ago in the same area.
Iodine uptake decreased significantly, from 40% (range 16-67%) in 1981-1993 to 25% (range 13-62%) in 2001-2003. 38 of the 42 patients were examined, and of these 34 (90%) had benefited from the treatment (53% of the 38 patients showed a complete effect) as estimated by the patient and the physician, based on the patient's original symptoms and the physician's clinical judgement. Four patients developed hypothyroidism, one radiation-induced thyroiditis and three Graves" disease.
Iodine uptake is significantly lowered after the addition of iodine to salt. Radioiodine therapy of nontoxic goiter will continue to be effective.
在食盐加碘后，对非毒性甲状腺肿的碘摄取及放射性碘治疗效果进行了研究。
对61例非毒性甲状腺肿患者（48例女性，13例男性，中位年龄56岁（范围28 - 78岁））进行回顾性研究，通过24小时放射性碘摄取进行检查。其中42例患者接受了放射性碘治疗（中位剂量600 MBq，范围200 - 600 MBq）。将结果与10年前在同一地区进行的一项研究结果进行比较。
碘摄取显著下降，从1981 - 1993年的40%（范围16 - 67%）降至2001 - 2003年的25%（范围13 - 62%）。对42例接受治疗的患者中的38例进行了检查，根据患者最初症状及医生临床判断，患者和医生估计其中34例（90%）从治疗中获益（38例患者中有53%显示出完全疗效）。4例患者出现甲状腺功能减退，1例发生放射性甲状腺炎，3例发生格雷夫斯病。
食盐加碘后碘摄取显著降低。非毒性甲状腺肿的放射性碘治疗仍将有效。
