Sennerby Lars, Persson Leif G, Berglundh Tord, Wennerberg Ann, Lindhe Jan
Department of Biomaterials, Institute for Surgical Sciences, Sahlgrenska Academy, University of Göteborg, Göteborg, Sweden.
Clin Implant Dent Relat Res. 2005;7(3):136-40. doi: 10.1111/j.1708-8208.2005.tb00057.x.
Histologic studies have demonstrated the possibility to reestablish direct bone-implant contacts after ligature-induced periimplantitis. The influence of the reosseointegration on the stability of implants is not known.
The aim of the present investigation was to study bone tissue and associated implant stability alterations that occurred during induction and resolution of periimplantitis using resonance frequency analysis (RFA), radiography, and histology.
Three implants with smooth (turned) or roughened (SLA) surfaces were placed in each side of the edentulous mandible of four dogs. Experimental periimplantitis was induced for 3 months. Five weeks later, the animals were treated with antibiotics and surgical therapy and were followed for another 6 months. Periapical radiographs and RFA were used to evaluate marginal bone levels and implant stability throughout the study period. After termination, the tissue-implant interface was evaluated by light microscopy in ground sections.
There was a linear relationship between radiographic and RFA findings because continuous loss of marginal bone and a decrease in implant stability were observed for both implant surfaces during the periimplantitis period. Antibiotic treatment and surgical therapy resulted in some reosseointegration, which was more marked for the SLA surface. The resonance frequency values corresponded well to the histometric measurements because reosseointegration resulted in an increase in implant stability.
The findings from the present study indicate a linear relationship between marginal bone level and resonance frequency value. It is suggested that the RFA technique is sensitive and may be used to detect even a minor change in the level of bone-implant contact.
组织学研究表明，在结扎诱导的种植体周围炎后重新建立直接的骨-种植体接触是可能的。但骨再整合对种植体稳定性的影响尚不清楚。
本研究的目的是使用共振频率分析（RFA）、放射ography和组织学研究种植体周围炎诱导和消退过程中发生的骨组织及相关种植体稳定性变化。
在四只狗的无牙下颌骨两侧各植入三枚表面光滑（车削）或粗糙（SLA）的种植体。诱导实验性种植体周围炎3个月。5周后，对动物进行抗生素和手术治疗，并随访6个月。在整个研究期间，使用根尖片和RFA评估边缘骨水平和种植体稳定性。实验结束后，通过光学显微镜对磨片上的组织-种植体界面进行评估。
放射ography和RFA结果之间存在线性关系，因为在种植体周围炎期间，两种种植体表面均观察到边缘骨持续丢失和种植体稳定性下降。抗生素治疗和手术治疗导致了一定程度的骨再整合，SLA表面更为明显。共振频率值与组织测量结果吻合良好，因为骨再整合导致种植体稳定性增加。
本研究结果表明边缘骨水平与共振频率值之间存在线性关系。建议RFA技术敏感，可用于检测骨-种植体接触水平的微小变化。
