Figueras Aloy J, Quero J, Doménech E, López Herrera M C, Izquierdo I, Losada A, Perapch J, Sánchez-Luna M
Hospital Clínic, Institut Clínic de Ginecología, Obstetricia y Neonatología, Universitat de Barcelona, Spain.
An Pediatr (Barc). 2005 Oct;63(4):357-62. doi: 10.1157/13079818.
Premature babies < or = 35 weeks gestation, with or without chronic lung disease (CLD), and infants affected by severe congenital heart disease should be considered high risk population for RSV infection and hospitalization. Hygienic measures and RSV monoclonal antibodies (palivizumab) have been found useful in decreasing rates of RSV hospitalization in these patients. Guidelines for their administration include: a) strongly recommended use in premature babies < or = 28 weeks gestation, or born between 29-32 weeks gestation and less than 6 months at start of RSV station or discharged along it, or affected by CLD in treatment during last 6 months or by severe congenital heart disease. Last two groups could be prophylaxed for two RSV seasons. b) Recommended use among premature babies between 32-35 weeks gestation and less than 6 months of age and presenting two or more risk factors: chronologic age < 10 weeks at start of RSV station, breastfeeding < or = 2 months (physician prescription), sibling < 14 years old, day-care assistance, family history of wheezing, > or = 4 adults at home, airways malformation or neuromuscular disease.
孕周小于或等于35周的早产儿，无论有无慢性肺病（CLD），以及患有严重先天性心脏病的婴儿，均应被视为呼吸道合胞病毒（RSV）感染和住院的高危人群。卫生措施和RSV单克隆抗体（帕利珠单抗）已被证明有助于降低这些患者的RSV住院率。其给药指南包括：a）强烈建议在孕周小于或等于28周的早产儿中使用，或在29 - 32周出生且在RSV流行季节开始时或期间出院时小于6个月的早产儿，或在过去6个月内接受CLD治疗或患有严重先天性心脏病的婴儿。后两组可预防两个RSV流行季节。b）建议在孕周为32 - 35周且小于6月龄且存在两个或更多危险因素的早产儿中使用：RSV流行季节开始时实足年龄小于10周、母乳喂养小于或等于2个月（医生处方）、同胞年龄小于14岁、接受日托、有喘息家族史、家中有≥4名成年人、气道畸形或神经肌肉疾病。
