Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.
作者信息
Chesworth Richard, Wessel Matthew D, Heyden Lisa, Mangano F Michael, Zawistoski Michael, Gegnas Laura, Galluzzo David, Lefker Bruce, Cameron Kimberly O, Tickner Jeanne, Lu Bihong, Castleberry Tessa A, Petersen Donna N, Brault Amy, Perry Pia, Ng Oicheng, Owen Thomas A, Pan Lydia, Ke Hua-Zhu, Brown Thomas A, Thompson David D, DaSilva-Jardine Paul
机构信息
Cardiovascular and Metabolic Diseases, Medicinal Chemistry, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA.
出版信息
Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. doi: 10.1016/j.bmcl.2005.08.010. Epub 2005 Oct 10.
A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported.
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