Bua Jenny, Marchetti Federico, Barbi Egidio, Sarti Armando, Ventura Alessandro
Department of Pediatrics, Institute of Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Pediatr Infect Dis J. 2005 Oct;24(10):934-5. doi: 10.1097/01.inf.0000180472.23898.7e.
A 1.5-year-old girl developed high frequency tremors and chorea after receiving a dose of 120 mg/kg/d trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of Pneumocystis pneumonia. The child was human immunodeficiency virus-negative but immunocompromised because of prolonged immunosuppressive therapy. These symptoms disappeared 3 days after TMP-SMX was discontinued. Pediatricians should be aware of tremors and chorea among the potential adverse effects of high doses of TMP-SMX.
一名1.5岁女童在接受120mg/kg/d剂量的复方新诺明（TMP-SMX）治疗肺孢子菌肺炎后出现高频震颤和舞蹈症。该患儿人类免疫缺陷病毒检测呈阴性，但因长期免疫抑制治疗而免疫功能低下。停用TMP-SMX 3天后这些症状消失。儿科医生应注意高剂量TMP-SMX的潜在不良反应中包括震颤和舞蹈症。
