Bohrer T, Fleischmann P, Tersteegen A, Hasse C
Klinik und Poliklinik für Herz- und Thoraxchirurgie, Julius-Maximilians-Universität Würzburg, Deutschland.
Zentralbl Chir. 2005 Oct;130(5):440-8. doi: 10.1055/s-2005-836820.
Aim of our study has been the systematic evaluation concerning the still farmost unknown disease of postoperative, permanent hypoparathyroidism. For this we designed a specific questionnaire as measuring instrument--it was evaluated by experts and validated by 3 control groups--to examine then a patient group (n = 20) with symptomatic postoperative, permanent hypoparathyroidism. The application of the questionnaire was very feasible, the reliability of measuring scales according to Cronbach's alpha > or = 0.70. The validity of content and construct validity fully existed (Pearson's correlation coefficient r > or = - 0.27; p < 0,05). The farmost frequent clinical complaints were peripheral cold sensations (65 %), pains in joints (55 %), sensation of heaviness and weakness in extremities (55 %) and paresthesias (45 %). Most frequent clinical symptoms were brittle nails (40 %) and diarrhoea (35 %). Sum and distress level scores for classification of illness severity were determined. In conclusion our questionnaire is a valid instrument and from a clinical point of view easy to apply, reasonable and very feasible in practical use. It represents a novel, optimum instrument to determine disease condition and illness severity of hypoparathyroid patients and makes it possible to gain further information of this up to now less systematically analysed disease.
我们研究的目的是对术后永久性甲状旁腺功能减退这一仍极为未知的疾病进行系统评估。为此，我们设计了一份特定问卷作为测量工具——该问卷经专家评估并由3个对照组验证——然后对一组有症状的术后永久性甲状旁腺功能减退患者（n = 20）进行调查。问卷的应用非常可行，根据克朗巴赫α系数，测量量表的信度≥0.70。内容效度和结构效度完全具备（皮尔逊相关系数r≥ - 0.27；p < 0.05）。最常见的临床主诉是外周冷感（65%）、关节疼痛（55%）、四肢沉重和无力感（55%）以及感觉异常（45%）。最常见的临床症状是指甲变脆（40%）和腹泻（35%）。确定了用于疾病严重程度分类的总分和痛苦程度评分。总之，我们的问卷是一种有效的工具，从临床角度来看易于应用、合理且在实际使用中非常可行。它是一种新颖、最佳的工具，可用于确定甲状旁腺功能减退患者的疾病状况和疾病严重程度，并有可能获取关于这种迄今为止较少进行系统分析的疾病的更多信息。
