Blomgren H, Kling-Andersson G
Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Anticancer Res. 1992 May-Jun;12(3):981-6.
In an attempt to find new methods for the treatment of malignant gliomas a number of tests have been performed to learn whether growth of such cells in vitro may be affected by agents which interfere with the biosynthesis of eicosanoids. It was observed that DNA-synthesis of short-term monolayer cultures could be blocked by compounds which inhibit cyclooxygenase and/or lipoxygenase dependent arachidonic acid metabolism. The strongest inhibitory activities were noted in serum-free culture medium using compounds interfering with the activity of lipoxygenases. One explanation of these results could be that the growth of human malignant gliomas is dependent on certain eicosanoids which may be synthesized by the malignant cells themselves.
为了寻找治疗恶性胶质瘤的新方法，已经进行了多项试验，以了解此类细胞在体外的生长是否会受到干扰类二十烷酸生物合成的药物的影响。据观察，抑制环氧化酶和/或脂氧合酶依赖性花生四烯酸代谢的化合物可阻断短期单层培养物的DNA合成。在使用干扰脂氧合酶活性的化合物的无血清培养基中观察到最强的抑制活性。这些结果的一种解释可能是人类恶性胶质瘤的生长依赖于某些可能由恶性细胞自身合成的类二十烷酸。
