Lim U, Schenk M, Kelemen L E, Davis S, Cozen W, Hartge P, Ward M H, Stolzenberg-Solomon R
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA.
Am J Epidemiol. 2005 Nov 15;162(10):953-64. doi: 10.1093/aje/kwi310. Epub 2005 Oct 12.
The role of dietary one-carbon determinants remains largely unexplored for non-Hodgkin's lymphoma (NHL). In a population-based case-control study of non-African-American adult (aged 20-74 years) women and men from four US Surveillance, Epidemiology, and End Results study centers (Detroit, Michigan; Iowa; Los Angeles, California; and Seattle, Washington; 1998-2000), the authors examined folate; vitamins B2, B6, and B12; methionine; and a one-carbon antagonist, alcohol, in 425 incident NHL cases and 359 controls who completed a detailed food frequency questionnaire. Adjusted odds ratios and 95% confidence intervals were estimated by using unconditional logistic regression. Higher intake of one-carbon determinants from food was associated with a lower risk of NHL, but that for only vitamin B6 (highest vs. lowest quartile: odds ratio = 0.57, 95% confidence interval: 0.34, 0.95; p trend = 0.01) and methionine (odds ratio = 0.49, 95% confidence interval: 0.31, 0.76; p trend = 0.002) reached statistical significance. Folate from food was inversely associated with diffuse subtype (odds ratio = 0.47, 95% confidence interval: 0.23, 0.94; p trend = 0.03). The authors found no association between total (food plus supplement) vitamins and NHL. Nonusers of alcohol had an elevated NHL risk compared with users, and alcohol did not modify other nutrient-NHL associations. Findings suggest that one-carbon nutrients, particularly vitamin B6 and methionine, may be protective against NHL.
饮食中一碳决定因素在非霍奇金淋巴瘤（NHL）中的作用在很大程度上仍未得到探索。在一项基于人群的病例对照研究中，研究对象为来自美国四个监测、流行病学和最终结果研究中心（密歇根州底特律；爱荷华州；加利福尼亚州洛杉矶；华盛顿州西雅图；1998 - 2000年）的非非裔美国成年（20 - 74岁）女性和男性，作者对425例新诊断的NHL病例和359名对照者进行了叶酸、维生素B2、B6和B12、蛋氨酸以及一种一碳拮抗剂酒精的检测，这些对照者完成了一份详细的食物频率问卷。采用无条件逻辑回归估计调整后的比值比和95%置信区间。从食物中摄入较高的一碳决定因素与较低的NHL风险相关，但只有维生素B6（最高四分位数与最低四分位数相比：比值比 = 0.57，95%置信区间：0.34，0.95；p趋势 = 0.01）和蛋氨酸（比值比 = 0.49，95%置信区间：0.31，0.76；p趋势 = 0.002）达到统计学显著性。食物中的叶酸与弥漫性亚型呈负相关（比值比 = 0.47，95%置信区间：0.23，0.94；p趋势 = 0.03）。作者发现总维生素（食物加补充剂）与NHL之间无关联。与饮酒者相比，不饮酒者患NHL的风险升高，且酒精并未改变其他营养素与NHL的关联。研究结果表明，一碳营养素，特别是维生素B6和蛋氨酸，可能对NHL具有保护作用。
