磺胺多辛-乙胺嘧啶和阿莫地喹在坦桑尼亚桑给巴尔单纯性恶性疟原虫疟疾儿童中的治疗效果。
Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.
作者信息
Lemnge Martha M, Ali Abdullah S, Malecela Ezekiel K, Sambu Edward, Abdulla Rahma, Juma Mohamed S, Fakih Khatibu, Abdulla Khafidh H, Njau Ritha J
机构信息
National Institute for Medical Research, Amani Medical Research Centre, Amani, Tanga, Tanzania.
出版信息
Am J Trop Med Hyg. 2005 Oct;73(4):681-5.
The efficacy of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) was assessed at Kivunge and Micheweni in Zanzibar, Tanzania, in 2001. The main objective was to obtain baseline data after observations of high levels of chloroquine treatment failures. Children (6-59 months) were randomized to receive either drug. At Kivunge, SP and AQ were given to 64 and 63 cases, while for Micheweni, 61 and 70 cases were treated. Main findings were overall high rates (> 90%) of adequate clinical response (ACR) with AQ. A lower ACR was seen in the SP group at Kivunge (87.1%) compared with Micheweni (94.8%). Furthermore, in the ACR group, 16.7% AQ parasitological resistance (RI-RIII) was encountered at Kivunge. Most of the cases of SP parasitological resistance (14.5%; RI/RII) were seen at Micheweni. Notwithstanding this, the overall treatment failure was only 9.2% with SP and 5.5% with AQ. The Zanzibar Ministry of Health has since reviewed its antimalarial drug policy.
2001年，在坦桑尼亚桑给巴尔的基温格和米切韦尼评估了周效磺胺-乙胺嘧啶（SP）和阿莫地喹（AQ）的疗效。主要目的是在观察到氯喹治疗失败率较高之后获取基线数据。儿童（6至59个月）被随机分配接受其中一种药物治疗。在基温格，64例和63例分别接受了SP和AQ治疗，而在米切韦尼，接受治疗的病例数分别为61例和70例。主要研究结果是，AQ的总体充分临床反应（ACR）率较高（>90%）。与米切韦尼（94.8%）相比，基温格的SP组ACR率较低（87.1%）。此外，在ACR组中，基温格出现了16.7%的AQ寄生虫学抗性（RI-RIII）。SP寄生虫学抗性的大多数病例（14.5%；RI/RII）出现在米切韦尼。尽管如此，SP的总体治疗失败率仅为9.2%，AQ为5.5%。此后，桑给巴尔卫生部审查了其抗疟药物政策。
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