Keller H H, Østbye T
Department of Family Relations and Applied Nutrition, University of Guelph, Guelph, ON, N1G 2W1.
J Nutr Health Aging. 2005 Sep-Oct;9(5):316-20.
Recently Canada adopted the World Health Organization's (WHO)Weight Classification system for Body Mass Index (BMI). To date, there has been minimal investigation on the predictive ability of BMI on mortality in seniors. This study investigates the predictive ability of the BMI categories identified in this Weight Classification System and change in BMI on mortality in Canadian seniors.
Canadian Study of Health and Aging (CSHA) participants who completed clinical examination (including body weight measurements) in 1991 (CSHA1) and 1996 (CSHA2) were included (n = 539). BMI change (CSHA1 to CSHA2) was categorized as no change/mild increase (0 to < 2.0 units), mild decrease (-0.1 to < -2.0 units), or significant increase/decrease (> or = +/-2.0 units). The outcome was subsequent 5-year-mortality, i.e. death between CSHA2 and CSHA3 (2001). Logistic regression controlled for age, gender, education level, marital status, smoking and cognitive status.
BMI at CSHA1 was not a significant predictor of all-cause mortality between CSHA2 and CSHA3. A significant decrease in BMI regardless of BMI category predicted death (OR 2.10 95% CI 1.17, 3.80). Other factors predictive of death were age and cognitive impairment without dementia.
A static measure of BMI is a less useful measure of mortality risk than weight change in older adults. Weight change, especially weight loss resulting in a BMI change of at least 2.0 units, is predictive of mortality and should be considered a warning sign.
最近加拿大采用了世界卫生组织(WHO)的体重指数(BMI)体重分类系统。迄今为止,关于BMI对老年人死亡率的预测能力的研究极少。本研究调查了该体重分类系统中确定的BMI类别以及BMI变化对加拿大老年人死亡率的预测能力。
纳入了在1991年(CSHA1)和1996年(CSHA2)完成临床检查(包括体重测量)的加拿大健康与老龄化研究(CSHA)参与者(n = 539)。BMI变化(从CSHA1到CSHA2)分为无变化/轻度增加(0至<2.0单位)、轻度下降(-0.1至<-2.0单位)或显著增加/下降(>或=+/-2.0单位)。结局为随后的5年死亡率,即CSHA2和CSHA3(2001年)之间的死亡情况。逻辑回归分析控制了年龄、性别、教育水平、婚姻状况、吸烟和认知状态。
CSHA1时的BMI并非CSHA2和CSHA3之间全因死亡率的显著预测指标。无论BMI类别如何,BMI显著下降均预示着死亡(比值比2.10,95%置信区间1.17,3.80)。其他预示死亡的因素包括年龄和无痴呆的认知障碍。
对于老年人,BMI的静态测量对死亡风险的预测作用不如体重变化有用。体重变化,尤其是导致BMI变化至少2.0单位的体重减轻,可预测死亡率,应被视为一个警示信号。