Albè Elena, Escalona Elizabeth, Rajagopal Rama, Javier Joel A, Chang Jin-Hong, Azar Dimitri T
Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
FEBS Lett. 2005 Oct 24;579(25):5481-6. doi: 10.1016/j.febslet.2005.08.078. Epub 2005 Sep 28.
The hyaloid vascular system (HVS) is a transient network of capillaries that nourishes the embryonic lens and the primary vitreous of the developing eye. We used proteomic analysis and immunohistochemical staining to identify activin receptor-like kinase-1 (ALK1), a type I receptor for transforming growth factor-beta1, during the HVS regression phase. In addition, we overexpressed ALK1 in corneas implanted with bFGF (basic fibroblast growth factor) pellets and observed that ALK1 overexpression resulted in inhibition of bFGF-induced corneal neovascularization in vivo. Our data suggest that ALK1 may play a role in HVS regression during ocular development.
玻璃体血管系统（HVS）是一个短暂的毛细血管网络，为胚胎晶状体和发育中眼睛的原始玻璃体提供营养。我们使用蛋白质组学分析和免疫组织化学染色，在HVS消退阶段鉴定了激活素受体样激酶-1（ALK1），它是转化生长因子-β1的I型受体。此外，我们在植入碱性成纤维细胞生长因子（bFGF）微丸的角膜中过表达ALK1，并观察到ALK1过表达在体内可抑制bFGF诱导的角膜新生血管形成。我们的数据表明，ALK1可能在眼部发育过程中的HVS消退中发挥作用。
