眼部发育过程中玻璃体血管系统退化的蛋白质组学分析。
Proteomic analysis of the hyaloid vascular system regression during ocular development.
作者信息
Albè Elena, Chang Jin-Hong, Azar Nathalie F, Ivanov Alexander R, Azar Dimitri T
机构信息
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
出版信息
J Proteome Res. 2008 Nov;7(11):4904-13. doi: 10.1021/pr800551m. Epub 2008 Oct 8.
Abstract
We describe a proteomic approach to investigate the differential protein expression patterns and identify the physiologically relevant angiogenic and antiangiogenic factors involved in the hyaloid vascular system regression. Differentially expressed proteins were identified using two-dimensional gel electrophoresis followed by nanoflow chromatography coupled with tandem mass spectrometry. These proteins are expected to provide insight as to their function in the early maintenance and eventual regression of the hyaloid vascular system.
摘要
我们描述了一种蛋白质组学方法，用于研究差异蛋白质表达模式，并鉴定参与玻璃体血管系统消退的生理相关血管生成和抗血管生成因子。使用二维凝胶电泳，随后进行纳流色谱与串联质谱联用，来鉴定差异表达的蛋白质。预计这些蛋白质将为其在玻璃体血管系统早期维持和最终消退中的功能提供深入了解。
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