Wierup M, Nord C E, Sjöberg L
Lab Anim. 1979 Jul;13(3):263-6. doi: 10.1258/002367779780937960.
The value of biotyping and phage-typing coagulase-negative staphylococci in the epidemiological investigation of a laboratory animal house was clearly demonstrated. In the animal rooms in which conventional bacteriological methods revealed equal bacterial contamination between a conventional unit and one housing specified-pathogen-free rodents, biotyping identified Staphylococcus cohnii as the only species in the latter, compared to S. warneri, S. hominis, S. saprophyticus. S. xylosus abd S. epidermidis as well as S. cohnii in the conventional unit. Similarly, phagetyping revealed 2 phage types in the specified-pathogen-free compared to 7 in the conventional unit. Thus biotyping and phage-typing provided evidence for the existence of a barrier between these units that had presented similar gross bacteriological findings.
生物分型和噬菌体分型在实验动物房流行病学调查中对凝固酶阴性葡萄球菌的价值得到了明确体现。在常规细菌学方法显示传统饲养单元和饲养无特定病原体啮齿动物的单元之间细菌污染程度相同的动物房中，生物分型鉴定出后者中仅存在科氏葡萄球菌，而传统饲养单元中存在华纳葡萄球菌、人葡萄球菌、腐生葡萄球菌、木糖葡萄球菌、表皮葡萄球菌以及科氏葡萄球菌。同样，噬菌体分型显示无特定病原体单元中有2种噬菌体类型，而传统饲养单元中有7种。因此，生物分型和噬菌体分型为这些呈现相似总体细菌学结果的单元之间存在屏障提供了证据。
