Lychkova A E
Central Research Institute of Gastroenterology, Moscow.
Bull Exp Biol Med. 2005 May;139(5):550-3. doi: 10.1007/s10517-005-0342-y.
Experiments were performed on nembutal-narcotized rabbits. To study motor activity of the large intestine stimulation was applied to the right vagus nerve and left sympathetic trunk, as well as to the right pelvic nerve and left sympathetic trunk. We found a decreasing gradient of serotoninergic innervation from the ascending colon to the transverse colon and rectum (45-50, 30-35, and 25-30%, respectively) during simultaneous stimulation of the sympathetic trunk and vagus nerve and an increasing gradient of serotoninergic innervation in the large intestine during simultaneous stimulation of the sympathetic trunk and pelvic nerve. Stimulation of serotoninergic fibers was accompanied by arterial spasm in the microcirculatory bed and venous congestion.
实验在戊巴比妥麻醉的兔子身上进行。为研究大肠的运动活性，对右侧迷走神经和左侧交感干以及右侧盆神经和左侧交感干施加刺激。我们发现，在交感干和迷走神经同时受到刺激时，从升结肠到横结肠和直肠的5-羟色胺能神经支配呈递减梯度（分别为45%-50%、30%-35%和25%-30%），而在交感干和盆神经同时受到刺激时，大肠内5-羟色胺能神经支配呈递增梯度。刺激5-羟色胺能纤维会伴有微循环床的动脉痉挛和静脉充血。
