Zhu Li, Shi Zhong-yuan, Wu Xiao-mei, Zhang Zhi-jun, Jin Shu-yi
Institute of Nautical Medicine, Nantong University, Nantong Jiangsu, China.
Space Med Med Eng (Beijing). 2005 Aug;18(4):303-5.
To observe the protective effects of Rhodiola-astragalus membranaceus mixture against brain damage during hypoxia under simulated plateau environment and the mechanisms maybe involved in.
Adult SD rats were randomly divided into 3 groups, which were normoxic control, simulated plateau hypoxia, and Rhodiola-astragalus membranaceus mixture pretreatment group. Rats in the latter two groups were exposed to simulated 8000 m altitude in a hypobaric chamber for 7 h. Water content, Na+, K(+)-ATPase activity and SOD activity in cerebral tissue, malondialdehyde (MDA) and lactic acid content in cerebral homogenate and serum were measured.
As compared with control group, cerebral water content was significantly higher in hypoxia group, while it was obviously lower in pretreatment group. MDA contents of hypoxia group both in cerebral homogenate and serum were higher than that of control group, while the pretreatment group they were both decreased obviously. Lactic acid content of hypoxia group in cerebral and in serum increased markedly and decreased drastically in pretreatment group compared to that of hypoxic group.
Rhodiola-astragalus membranaceus mixture has preventive effects on hypoxic damage induced by simulated plateau environment. This prevention may be related to the antagonistic effect on membrane lipid peroxidation and the inhibition on the accumulation of lactic acid in brain tissue and serum.
观察红景天-黄芪合剂对模拟高原环境下缺氧时脑损伤的保护作用及其可能的作用机制。
将成年SD大鼠随机分为3组，即常氧对照组、模拟高原缺氧组和红景天-黄芪合剂预处理组。后两组大鼠置于低压舱中模拟海拔8000 m环境7 h。检测脑组织含水量、Na+、K(+)-ATP酶活性及超氧化物歧化酶（SOD）活性，以及脑匀浆和血清中丙二醛（MDA）和乳酸含量。
与对照组相比，缺氧组脑组织含水量显著升高，而预处理组明显降低。缺氧组脑匀浆和血清中MDA含量均高于对照组，而预处理组均明显降低。缺氧组脑和血清中乳酸含量显著升高，与缺氧组相比，预处理组明显降低。
红景天-黄芪合剂对模拟高原环境所致的缺氧损伤有预防作用。这种预防作用可能与拮抗膜脂质过氧化及抑制脑组织和血清中乳酸蓄积有关。
