Warren R B, Griffiths C E M
Department of Dermatology, Royal Liverpool and Broadgreen Hospital, Liverpool L14 3LB, UK.
Br J Dermatol. 2005 Nov;153(5):869-73. doi: 10.1111/j.1365-2133.2005.06880.x.
The study of pharmacogenetics will optimize the use of systemic therapies in dermatology. Directed prescription of azathioprine dependent on phenotypic expression of the thiopurine methyltransferase gene is now accepted practice. To some extent other, older drugs have been neglected. We look at the role that pharmacogenetics could play in the use of methotrexate for psoriasis, focusing on known polymorphisms in the folate metabolic pathway.
药物遗传学的研究将优化皮肤病学中全身治疗的应用。根据硫嘌呤甲基转移酶基因的表型表达来指导硫唑嘌呤的处方现已成为公认的做法。在某种程度上，其他较老的药物则被忽视了。我们探讨了药物遗传学在甲氨蝶呤治疗银屑病中的作用，重点关注叶酸代谢途径中已知的基因多态性。
