乙酰水杨酸在体外增强乙醇脱氢酶活性。
Enhancement of alcohol dehydrogenase activity in vitro by acetylsalicylic acid.
作者信息
Negoro Munetaka, Wakabayashi Ichiro
机构信息
Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan.
出版信息
Eur J Pharmacol. 2005 Oct 31;523(1-3):25-8. doi: 10.1016/j.ejphar.2005.08.049. Epub 2005 Oct 13.
The interaction of acetylsalicylic acid with alcohol dehydrogenase was investigated. Horse liver alcohol dehydrogenase bound to a p-hydroxyacetophenone affinity column was eluted by acetylsalicylic acid. In vitro enzymatic activity of alcohol dehydrogenase in the presence of ethanol as a substrate was significantly increased by incubation with acetylsalicylic acid. These results suggest that acetylsalicylic acid has an affinity with alcohol dehydrogenase and enhances its activity.
研究了乙酰水杨酸与乙醇脱氢酶的相互作用。结合在对羟基苯乙酮亲和柱上的马肝乙醇脱氢酶被乙酰水杨酸洗脱。在以乙醇为底物的情况下，通过与乙酰水杨酸孵育，乙醇脱氢酶的体外酶活性显著增加。这些结果表明乙酰水杨酸与乙醇脱氢酶具有亲和力并增强其活性。
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