Melo-Filho Antonio A, Vinagre Adriana M, Collares Edgard F, Bustorff-Silva Joaquim M
Division of Pediatric Surgery, Department of Surgery, State University of Campinas, Campinas-SP 13083-970, Brazil.
J Pediatr Surg. 2005 Oct;40(10):1551-6. doi: 10.1016/j.jpedsurg.2005.06.006.
BACKGROUND/PURPOSE: The aim of this study is to evaluate the early and late effects of partial fundoplication (PFp) and total fundoplication (TFp) on gastric emptying (GE) and on gastric compliance (GC) in rats.
One hundred fifty-nine male Wistar rats, 6 to 8 weeks of age and weighing 150 to 250 g underwent sham operation, PFp or TFp. They were randomly divided into early group (group E) and late group (group L), evaluated on the 7th and 28th postoperative days, respectively. Gastric emptying studies were performed with and without short-term induction of GE delay.
Gastric emptying studies: In group E, TFp altered gastric retention when compared with sham subgroup in rats with GE delay. In group L, neither PFp nor TFp produced changes in GE. Gastric volume-gastric compliance studies: In group E, only TFp reduced significantly gastric volume, but both PFp and TFp caused a significant decrease in GC. A trend toward normalization of gastric volume and GC was perceived in group L. Partial fundoplication did not change the intragastric pressure response in either group E or group L. Total fundoplication increased the intragastric pressure significantly in group E, but this difference disappeared on the 28th postoperative day.
Partial fundoplication induces less change in gastric motor physiology than TFp. These findings provide background to explain some differences in the postoperative course after PFp and TFp.
背景/目的：本研究旨在评估部分胃底折叠术（PFp）和完全胃底折叠术（TFp）对大鼠胃排空（GE）和胃顺应性（GC）的早期和晚期影响。
159只6至8周龄、体重150至250克的雄性Wistar大鼠接受假手术、PFp或TFp。它们被随机分为早期组（E组）和晚期组（L组），分别在术后第7天和第28天进行评估。在有和没有短期诱导GE延迟的情况下进行胃排空研究。
胃排空研究：在E组中，与GE延迟大鼠的假手术亚组相比，TFp改变了胃潴留情况。在L组中，PFp和TFp均未引起GE的变化。胃容积-胃顺应性研究：在E组中，只有TFp显著降低了胃容积，但PFp和TFp均导致GC显著降低。在L组中观察到胃容积和GC有恢复正常的趋势。部分胃底折叠术在E组和L组中均未改变胃内压反应。完全胃底折叠术在E组中显著增加了胃内压，但这种差异在术后第28天消失。
部分胃底折叠术对胃运动生理学的影响比TFp小。这些发现为解释PFp和TFp术后过程中的一些差异提供了背景。
