Marshall Audrey C, Tworetzky Wayne, Bergersen Lisa, McElhinney Doff B, Benson Carol B, Jennings Russell W, Wilkins-Haug Louise E, Marx Gerald R, Lock James E
Department of Cardiology and Department of Surgery, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
J Pediatr. 2005 Oct;147(4):535-9. doi: 10.1016/j.jpeds.2005.04.055.
To describe technical aspects of successful fetal aortic valvuloplasty, with particular attention to balloon size.
We retrospectively reviewed all procedural records and echocardiograms pertaining to 26 attempts at fetal aortic valve dilation performed at a single center over a period of 4 years. We assessed the effect of valvuloplasty as determined by echocardiographic appearance at the time of intervention and in follow-up.
In 20 of 26 fetuses who had technically successful aortic valve dilation (median balloon:annulus ratio=1.1), all had improved antegrade flow and 12 had at least mild regurgitation after dilation. Use of an oversized balloon was associated with the onset of moderate or severe aortic regurgitation, seen in 5 fetuses. This aortic regurgitation was well tolerated and improved through the remainder of gestation.
These data imply that fetal aortic valves can be dilated safely with larger balloons than are commonly used for postnatal dilation. The observation of spontaneous improvement in postdilation aortic regurgitation further suggests that fetal valve tissue behaves uniquely.
描述成功进行胎儿主动脉瓣成形术的技术要点,尤其关注球囊大小。
我们回顾性分析了4年间在单一中心进行的26例胎儿主动脉瓣扩张术的所有手术记录和超声心动图。我们评估了干预时及随访时超声心动图表现所确定的瓣膜成形术效果。
在26例技术上成功进行主动脉瓣扩张的胎儿中,有20例(球囊与瓣环比值中位数 = 1.1),所有胎儿的前向血流均有改善,12例在扩张后至少有轻度反流。使用过大球囊与5例胎儿出现中度或重度主动脉反流有关。这种主动脉反流耐受性良好,并在妊娠剩余时间有所改善。
这些数据表明,与通常用于产后扩张的球囊相比,胎儿主动脉瓣可以用更大的球囊安全地扩张。扩张后主动脉反流自发改善的观察结果进一步表明,胎儿瓣膜组织表现独特。