Stepień Karolina, Tomaszewski Michał, Czuczwar Stanisław J
Department of Pathophysiology, Skubiszewski Medical University of Lublin, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Pharmacol Rep. 2005 Sep-Oct;57(5):561-9.
Treatment with statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) reduces the risk of ischemic stroke among patients with increased risk of vascular disease. Recent experimental data point to neuroprotective properties of statins in acute cerebral ischemia. There is a proven link between bioavailability of nitric oxide and the activity of statins and ischemic stroke. Due to their ability to up-regulate nitric oxide synthase, statins have been considered in the therapy of a number of the central nervous system disorders, including cerebral ischemia, Alzheimer's disease, Parkinson's disease, tumors, and trauma. It has been claimed that they suppress inflammatory response and secondary injury after acute ischemia.
使用他汀类药物（3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂）治疗可降低血管疾病风险增加患者发生缺血性卒中的风险。最近的实验数据表明他汀类药物在急性脑缺血中具有神经保护特性。一氧化氮的生物利用度与他汀类药物的活性及缺血性卒中之间存在已被证实的联系。由于他汀类药物能够上调一氧化氮合酶，因此已被考虑用于多种中枢神经系统疾病的治疗，包括脑缺血、阿尔茨海默病、帕金森病、肿瘤和创伤。据称，它们可抑制急性缺血后的炎症反应和继发性损伤。
