Juźwiak Stefania, Wójcicki Jerzy, Mokrzycki Krzysztof, Marchlewicz Mariola, Białecka Monika, Wenda-Rózewicka Lidia, Gawrońska-Szklarz Barbara, Droździk Marek
Department of Pharmacology, Pomeranian Medical University, Powstańców Wlkp. 72, PL 70-111 Szczecin, Poland.
Pharmacol Rep. 2005 Sep-Oct;57(5):604-9.
Cardiovascular disease is currently the leading cause of death in the West, and a search for factors limiting its occurrence is ongoing. Accumulated data indicate that quercetin, the major flavonol in the plant kingdom, may possess beneficial effects in atherosclerosis. The present study aimed at determination of effects of quercetin on hyperlipidemia and development of atherosclerotic lesions in two animal models, i.e. diet induced hyperlipidemia and aortic atherosclerosis, and in injured carotid artery in rabbits fed high-fat diet for 12 and 4 weeks, respectively. It was demonstrated that quercetin was effective in reducing serum triglycerides and cholesterol levels elevated by high-fat diet, after 12 weeks of the experiment. This activity was less prominent in the 4-week study in injured carotid artery rabbit model. Hypolipemic properties of the flavonoid were associated with the reduced formation of atherosclerotic plaques, both in the aorta (12-week study) as well as within injured carotid artery (4-week study) in high-fat diet-fed animals. The surface of the intima covered with atherosclerotic plaques in high-fat diet-fed rabbits was 24.6 +/- 33.1% in comparison to 0.7 +/- 1.3% (p < 0.05) in quercetin and high-fat diet supplemented animals. It is evident from the present study that quercetin possesses both hypolipemic and antiatherogenic properties.
心血管疾病目前是西方的主要死因，人们正在寻找限制其发生的因素。积累的数据表明，槲皮素作为植物界主要的黄酮醇，可能对动脉粥样硬化具有有益作用。本研究旨在确定槲皮素对两种动物模型（即饮食诱导的高脂血症和主动脉粥样硬化）以及分别喂食高脂饮食12周和4周的家兔颈总动脉损伤后高脂血症和动脉粥样硬化病变发展的影响。实验12周后表明，槲皮素能有效降低高脂饮食引起的血清甘油三酯和胆固醇水平。在颈总动脉损伤的家兔模型4周研究中，这种活性不太明显。在喂食高脂饮食的动物中，无论是在主动脉（12周研究）还是在颈总动脉损伤部位（4周研究），该类黄酮的降血脂特性都与动脉粥样硬化斑块形成减少有关。喂食高脂饮食的家兔中，覆盖有动脉粥样硬化斑块的内膜表面为24.6±33.1%，而在补充了槲皮素和高脂饮食的动物中为0.7±I.3%（P<0.05）。从本研究可以明显看出，槲皮素具有降血脂和抗动脉粥样硬化特性。
