Yongbi N M, Leach M O, Payne G S, Collins D J
CRC Clinical Magnetic Resonance Research Group, Royal Marsden Hospital, Sutton, Surrey, UK.
NMR Biomed. 1992 Mar-Apr;5(2):95-100. doi: 10.1002/nbm.1940050208.
A technique for obtaining T1 values from well localized regions using surface coils and with a clinically practicable measurement time is described. The method uses a two-point Inversion-Recovery/Saturation-Recovery (IR/SR) sequence in conjunction with the image-selected in vivo spectroscopy localization scheme. T1 values are obtained by comparing the ratio of peak areas with those in a pre-computed look-up table. The method was tested by measuring the T1s of six calibrated water phantoms doped with different concentrations of gadolinium. This indicated an accuracy of 3% for T1 values in the range 400-1500 ms. 31P spectra and T1 values of Pi, phosphocreatine and alpha-, beta- and gamma-NTP metabolites from the calf muscle of healthy volunteers were obtained with the sequence employing beta 1-insensitive excitation pulses and a surface coil. The T1 values fall within the range of published values obtained by other techniques.
本文描述了一种使用表面线圈从局部区域获取T1值的技术，该技术具有临床可行的测量时间。该方法使用两点反转恢复/饱和恢复（IR/SR）序列，并结合体内磁共振波谱成像选择的定位方案。通过将峰面积比与预先计算的查找表中的值进行比较来获得T1值。通过测量六个掺杂不同浓度钆的校准水模体的T1值对该方法进行了测试。这表明在400 - 1500毫秒范围内，T1值的准确度为3%。使用β1不敏感激发脉冲和表面线圈的序列，获得了健康志愿者小腿肌肉中无机磷酸盐（Pi）、磷酸肌酸以及α-、β-和γ-三磷酸核苷酸（NTP）代谢物的31P谱和T1值。这些T1值落在通过其他技术获得的已发表值范围内。
