昼行性和夜行性哺乳动物角膜上皮中的乙酰胆碱
Acetylcholine in the corneal epithelium of diurnal and nocturnal mammals.
作者信息
Ringvold Amund, Reubsaet J Leon E
机构信息
Eye Department, National Hospital, University of Oslo, Norway.
出版信息
Cornea. 2005 Nov;24(8):1000-3. doi: 10.1097/01.ico.0000160972.96447.45.
PURPOSE
To analyze the concentration of acetylcholine (ACh) in the corneal epithelium and aqueous humor of various diurnal and nocturnal mammals.
METHODS
The following species were examined: roe deer, cattle, horse, human, moose, sheep, reindeer, wild boar, polecat, lynx, cat, and rat. ACh was determined by liquid chromatography-tandem mass spectrometry.
RESULTS
ACh was present in significant amounts in the corneal epithelium of all diurnal mammals, the concentrations varying from one species to the next. By contrast, it was not detected in any of the nocturnal tissue samples. None of the species showed detectable amounts of ACh in the aqueous humor.
CONCLUSIONS
The amount of ACh in the corneal epithelium varies from one species to the next, with diurnal species showing significant concentrations and nocturnal species no detectable concentrations.
目的
分析不同昼行性和夜行性哺乳动物角膜上皮和房水中乙酰胆碱（ACh）的浓度。
方法
检测了以下物种：狍、牛、马、人、驼鹿、绵羊、驯鹿、野猪、鸡貂、猞猁、猫和大鼠。采用液相色谱-串联质谱法测定ACh。
结果
所有昼行性哺乳动物的角膜上皮中均存在大量ACh，其浓度因物种而异。相比之下，在任何夜行性组织样本中均未检测到ACh。所有物种的房水中均未检测到可检测量的ACh。
结论
角膜上皮中ACh的含量因物种而异，昼行性物种显示出显著浓度，夜行性物种未检测到浓度。
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