Louerat C, Depagne C, Nesme P, Biron F, Guerin J C
Service de pneumologie, Hôpital de la Croix Rousse, CHU Lyon, France.
Rev Mal Respir. 2005 Jun;22(3):473-6. doi: 10.1016/s0761-8425(05)85575-5.
We report the case of a patient suffering from disseminated actinomycosis.
A fifty-two year old man, who was both a heavy smoker and an alcoholic, was admitted to hospital with confusion associated with a pseudo-tumoral right upper lobe pneumonia. Brain computed tomography was normal on the day of admission but when repeated fifteen days later four lesions were seen with appearances suspicious of metastatic malignant disease. The isolation of Actinomyces odontolyticus in the bronchoalveolar lavage culture and the absence of evidence for neoplastic disease despite extensive investigation led to a diagnosis of disseminated actinomycosis with pulmonary and cerebral involvement. The patient's clinical condition improved with antibiotic therapy. The disseminated form of this infection as well as presentation with multifocal brain abscesses is rare.
The diagnosis of actinomycosis is problematic because it is an uncommon infection and microbiological identification is often difficult and delayed. It should be considered when clinical presentation suggests malignant disease but there is no histological confirmation.
我们报告一例播散性放线菌病患者的病例。
一名52岁男性,有重度吸烟和酗酒史,因与右上叶假瘤性肺炎相关的意识模糊入院。入院当天脑部计算机断层扫描正常,但15天后复查时发现4个病灶,表现疑似转移性恶性疾病。支气管肺泡灌洗培养中分离出溶齿放线菌,尽管进行了广泛检查但无肿瘤性疾病证据,最终诊断为累及肺部和脑部的播散性放线菌病。患者经抗生素治疗后临床状况改善。这种感染的播散形式以及多灶性脑脓肿表现较为罕见。
放线菌病的诊断存在问题,因为它是一种罕见感染,微生物鉴定通常困难且延迟。当临床表现提示恶性疾病但无组织学证实时应考虑该病。