Finkel Toren
Cardiovascular Branch ofthe National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.
Nat Rev Mol Cell Biol. 2005 Dec;6(12):971-6. doi: 10.1038/nrm1763.
The incidence of many diseases rises sharply with age. Although clearly separable, ageing and certain age-related diseases might share common mechanisms. Cellular metabolism and subsequent generation of reactive oxygen species might contribute both to the rate at which we age and to our susceptibility to numerous chronic diseases, therefore therapies that directly target the ageing process might provide new ways to treat human diseases.
许多疾病的发病率会随着年龄的增长而急剧上升。尽管衰老和某些与年龄相关的疾病明显可区分，但它们可能具有共同的机制。细胞代谢以及随后活性氧的产生可能既影响我们衰老的速度，又影响我们对众多慢性疾病的易感性，因此直接针对衰老过程的疗法可能为治疗人类疾病提供新途径。
