D'Cruz Louise M, Klein Ludger
Research Institute of Molecular Pathology, 1030 Vienna, Austria.
Nat Immunol. 2005 Nov;6(11):1152-9. doi: 10.1038/ni1264. Epub 2005 Oct 16.
Interleukin 2 signaling is believed to be critically involved in several aspects of CD25(+) CD4(+) regulatory T cell biology, such as intrathymic development, peripheral survival and suppressive function. Here we have analyzed the effects of interleukin 2 or CD25 deficiency on agonist-driven thymic development and the peripheral homeostasis of an antigen-specific population of regulatory T cells positive for forkhead family transcription factor Foxp3 and have correlated our observations with polyclonal suppressor populations. We found that the differentiation, acquisition of functional capacity and formation of a sizeable pool of suppressor T cells in the thymus was independent of interleukin 2 signaling, but that interleukin 2 was essential for the survival of mature Foxp3(+) regulatory T cells.
白细胞介素2信号传导被认为在CD25(+) CD4(+)调节性T细胞生物学的几个方面起着关键作用，如胸腺内发育、外周存活和抑制功能。在此，我们分析了白细胞介素2或CD25缺乏对激动剂驱动的胸腺发育以及叉头家族转录因子Foxp3阳性的抗原特异性调节性T细胞群体的外周稳态的影响，并将我们的观察结果与多克隆抑制细胞群体进行了关联。我们发现，胸腺中抑制性T细胞的分化、功能能力的获得以及相当数量细胞库的形成与白细胞介素2信号传导无关，但白细胞介素2对于成熟Foxp3(+)调节性T细胞的存活至关重要。
