Roof Katherine A, Hopkins William D, Izard M Kay, Hook Michelle, Schapiro Steven J
Division of Psychobiology, Yerkes National Primate Research Center, Atlanta, Georgia 30322, USA.
Am J Primatol. 2005 Oct;67(2):199-207. doi: 10.1002/ajp.20177.
As early as the 1970s, it was suggested that nonhuman primates may serve as models of human reproductive senescence. In the present study, the reproductive outcomes of 1,255 pregnancies in captive chimpanzees (Pan troglodytes) were examined in relation to parity and its covariate, maternal age. The results show that the percentage of positive pregnancy outcomes was negatively correlated with increasing parity. In addition, spontaneous abortions, stillbirths, and caesarian sections (C-sections) were positively correlated with increasing parity. Maternal age, rather than parity, was found to be the most important predictor of negative birth outcome. This study supports research demonstrating reproductive decline and termination in nonhuman primates, and is the first to quantitatively account for this phenomenon in captive female chimpanzees.
早在20世纪70年代,就有人提出非人类灵长类动物可作为人类生殖衰老的模型。在本研究中,对圈养黑猩猩(Pan troglodytes)的1255次妊娠的生殖结果进行了检查,这些结果与产次及其协变量(产妇年龄)相关。结果表明,阳性妊娠结果的百分比与产次增加呈负相关。此外,自然流产、死产和剖宫产与产次增加呈正相关。研究发现,产妇年龄而非产次是负面出生结果的最重要预测因素。本研究支持了关于非人类灵长类动物生殖能力下降和终止的研究,并且首次对圈养雌性黑猩猩中的这一现象进行了定量分析。