双侧颈静脉结扎对猫颅内压和脑脊液流出阻力的影响。

Effects of bilateral jugular vein ligation on intracranial pressure and cerebrospinal fluid outflow resistance in cats.

作者信息

Kotani J, Nitta K, Sakuma Y, Sugioka S, Fujita N, Ueda Y

机构信息

Department of Anesthesiology, Osaka Dental University, Japan.

出版信息

Br J Oral Maxillofac Surg. 1992 Jun;30(3):171-3. doi: 10.1016/0266-4356(92)90151-8.

DOI:10.1016/0266-4356(92)90151-8

PMID:1622962

Abstract

In order to study the effect of jugular venous outflow obstruction on intracranial pressure and cerebrospinal fluid (CSF) reabsorption capability, changes in epidural pressure (EDP) and CSF outflow resistance (Ro) were examined following bilateral jugular vein ligation in cats. EDP increased significantly (P less than 0.01) immediately after ligation from the control value of 4.9 +/- 0.5 mmHg (mean +/- SEM) to 15.9 +/- 0.9 mmHg. Thereafter, EDP gradually decreased back toward the control value. The pressure level had decreased to 6.7 +/- 0.5 mmHg by 20 minutes after ligation. The mean Ro was significantly (P less than 0.01) higher in the ligation group (200.4 +/- 9.7 mmHg/ml/min) that in the non-ligation group (120.0 +/- 9.9 mmHg/ml/min). These results suggest that bilateral jugular vein ligation impairs CSF reabsorption.

摘要

为研究颈静脉流出道梗阻对颅内压及脑脊液（CSF）重吸收能力的影响，在猫双侧颈静脉结扎后检测硬膜外压力（EDP）及脑脊液流出阻力（Ro）的变化。结扎后EDP立即从对照值4.9±0.5 mmHg（均值±标准误）显著升高（P<0.01）至15.9±0.9 mmHg。此后，EDP逐渐回落至对照值。结扎后20分钟时压力水平已降至6.7±0.5 mmHg。结扎组的平均Ro（200.4±9.7 mmHg/ml/min）显著高于未结扎组（120.0±9.9 mmHg/ml/min）（P<0.01）。这些结果提示双侧颈静脉结扎会损害脑脊液重吸收。