免疫分析的表面增强拉曼散射研究

Surface-enhanced Raman scattering studies on immunoassay.

作者信息

Xu Shuping, Ji Xiaohui, Xu Weiqing, Zhao Bing, Dou Xiaoming, Bai Yubai, Ozaki Yukihiro

机构信息

Jilin University, Key Laboratory for Supramolecular Structure and Material of Ministry of Education, Changchun 130012, People's Republic of China.

出版信息

J Biomed Opt. 2005 May-Jun;10(3):031112. doi: 10.1117/1.1915487.

DOI:10.1117/1.1915487

PMID:16229637

Abstract

Surface-enhanced Raman scattering (SERS) has recently been a matter of keen interest from the points of both basic science and applications because by using the SERS effect one can obtain Raman signals even from a single molecule. Immunoassay is one of the most promising fields in the applications of SERS, and the purpose of this review paper is to discuss the potential of SERS in immunoassay. This paper consists of four parts work on the indirect and direct methods of immunoassay via SERS. These methods provide the laboratorial attempts on biomedical diagnostic applications of SERS.

摘要

表面增强拉曼散射（SERS）近来无论是在基础科学还是应用领域都备受关注，因为利用SERS效应甚至可以从单个分子获得拉曼信号。免疫分析是SERS应用中最具前景的领域之一，本文的目的是探讨SERS在免疫分析中的潜力。本文包括四个部分，介绍了通过SERS进行免疫分析的间接和直接方法。这些方法为SERS在生物医学诊断应用方面提供了实验室尝试。