Dong C, Li W-D, Li D, Price R A
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104-6140, USA.
Int J Obes (Lond). 2006 Feb;30(2):388-90. doi: 10.1038/sj.ijo.0803119.
This study was conducted to explore the association between attempted suicides and body mass index (BMI, kg/m2) in a family sample of 2547 individuals. As a comparison, a national NESARC (the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions) sample of 41 589 individuals was included to validate the observed association. Compared to average weight, extreme obesity showed significantly increased odds for attempted suicides both in family sample (odds ratio (OR) = 3.37 and 95% confidence interval (CI) = 1.59-7.13 for BMI = 40- < 50 kg/m2; OR = 3.85 and 95% CI = 1.71-8.66 for BMI > or = 50 kg/m2) and in NESARC sample (OR = 2.11 and 95% CI = 1.59-2.81 for BMI = 40- < 50 kg/m2; OR = 2.56 and 95% CI = 1.34-4.92 for BMI> or = 50 kg/m2) after adjustment for sociodemographic factors. Compared to general population, the risk for attempted suicide was 87 and 122% higher for those with BMI=40- < 50 and > or = 50 kg/m2, respectively. The pattern of results in the family and population studies indicates that extreme obesity is strongly associated with attempted suicide.
本研究旨在探讨一个包含2547名个体的家庭样本中自杀未遂与体重指数（BMI，kg/m²）之间的关联。作为对照，纳入了一个由41589名个体组成的全国性NESARC（2001 - 2002年全国酒精及相关状况流行病学调查）样本，以验证观察到的关联。与平均体重相比，在调整社会人口学因素后，极端肥胖在家庭样本（BMI = 40 - < 50 kg/m²时，比值比（OR）= 3.37，95%置信区间（CI）= 1.59 - 7.13；BMI≥50 kg/m²时，OR = 3.85，95% CI = 1.71 - 8.66）和NESARC样本（BMI = 40 - < 50 kg/m²时，OR = 2.11，95% CI = 1.59 - 2.81；BMI≥50 kg/m²时，OR = 2.56，95% CI = 1.34 - 4.92）中均显示出自杀未遂的几率显著增加。与一般人群相比，BMI = 40 - < 50 kg/m²和≥50 kg/m²的人群自杀未遂风险分别高出87%和122%。家庭研究和人群研究的结果模式表明，极端肥胖与自杀未遂密切相关。
