Kessler H, Mierke D F, Saulitis J, Seip S, Steuernagel S, Wein T, Will M
Organisch Chemisches Institut der Technischen Universität München, Germany.
Biopolymers. 1992 Apr;32(4):427-33. doi: 10.1002/bip.360320420.
The constitution and configuration of Ro 09-0198 (cinnamycin) have been determined in DMSO. Further investigations in aqueous solution, in SDS micelles and in a lipid bilayer have been done to study the influence of different environments on the conformation of the peptide. It turned out that in spite of the polycyclic structure of the molecule, the conformation is drastically changed going from water to SDS micelles. Ro 09-0198 orients itself in lipid bilayers as expected from its amphiphilic structure. According to a nuclear Overhauser effect spectroscopy experiment under magic angle spinning (MAS) conditions, the molecule is incorporated into the membrane with its hydrophobic part inside the bilayer.
已在二甲基亚砜中确定了Ro 09-0198（肉桂霉素）的结构和构型。还在水溶液、十二烷基硫酸钠（SDS）胶束和脂质双层中进行了进一步研究，以探讨不同环境对该肽构象的影响。结果表明，尽管该分子具有多环结构，但从水相到SDS胶束，其构象发生了显著变化。Ro 09-0198根据其两亲性结构在脂质双层中自行排列。根据魔角旋转（MAS）条件下的核Overhauser效应光谱实验，该分子以其疏水部分位于双层内部的方式融入膜中。
