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Modern treatment of lung cancer: case 1. Amplification and mutation of the epidermal growth factor receptor in metastatic lung cancer with remission from gefitinib.

作者信息

Schwab Richard, Pinter Ferenc, Moldavy Judit, Papay Judi, Strausz Janos, Kopper Laszlo, Keri Gyorgy, Pap Akos, Petak Istvan, Oreskovich Karoly, Mangel Laszlo

机构信息

Rational Drug Design Laboratories CRC, Budapest.

出版信息

J Clin Oncol. 2005 Oct 20;23(30):7736-8. doi: 10.1200/JCO.2005.02.4760.

DOI:10.1200/JCO.2005.02.4760
PMID:16234532
Abstract
摘要

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Modern treatment of lung cancer: case 1. Amplification and mutation of the epidermal growth factor receptor in metastatic lung cancer with remission from gefitinib.肺癌的现代治疗:病例1。转移性肺癌中表皮生长因子受体的扩增与突变及吉非替尼治疗后缓解
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Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.肺癌的遗传易感性可能与表皮生长因子受体(EGFR)中的T790M耐药突变有关。
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PLoS One. 2013;8(1):e54294. doi: 10.1371/journal.pone.0054294. Epub 2013 Jan 18.
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Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas.肺腺癌中 EGFR 表达、拷贝数与突变的关系。
BMC Cancer. 2010 Jul 19;10:376. doi: 10.1186/1471-2407-10-376.
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Epidermal growth factor receptor (EGFR) high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by standard immunohistochemistry.
在肺腺癌中,表皮生长因子受体(EGFR)高基因拷贝数和激活突变并不总是伴随着标准免疫组织化学检测的EGFR蛋白阳性。
J Mol Diagn. 2008 Mar;10(2):160-8. doi: 10.2353/jmoldx.2008.070125. Epub 2008 Feb 7.