Burns S Joyce, Foss Alexander J E, Butler Tom K H
University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.
Ophthalmic Plast Reconstr Surg. 2005 Sep;21(5):353-5. doi: 10.1097/01.iop.0000176273.32152.70.
To determine the long-term outcome of periocular sebaceous gland carcinoma and factors predictive of tumor recurrence.
A retrospective case note review of all patients with periocular sebaceous gland carcinoma treated at the Queen's Medical Centre, Nottingham, United Kingdom, between 1992 and 1999. Patient age at time of surgery, tumor location, and treatment were recorded. The tumor dimensions and histopathologic description were correlated with tumor recurrence. The general practitioners were contacted to determine whether there had been any further tumor recurrences since the last entry in the hospital notes.
A total of 11 cases (mean age, 75 years) were reviewed, of which 7 were female. The eyelids were involved in all but 2 cases, and maximum tumor dimension ranged from 6 to 25 mm. Three demonstrated pagetoid spread. Recurrence was seen in all tumors reported as incompletely excised (4 cases), of which only one demonstrated pagetoid spread. Tumour size was not predictive of recurrence.
In our unit, the best prognostic factor for sebaceous gland carcinoma is a histologic report confirming complete excision of the tumor, whatever the tumor size or pattern of spread identified.
确定眼周皮脂腺癌的长期预后以及预测肿瘤复发的因素。
对1992年至1999年间在英国诺丁汉女王医疗中心接受治疗的所有眼周皮脂腺癌患者的病历进行回顾性分析。记录手术时患者的年龄、肿瘤位置和治疗情况。将肿瘤大小和组织病理学描述与肿瘤复发情况进行关联分析。联系全科医生以确定自医院记录的最后一次记录以来是否有任何进一步的肿瘤复发。
共回顾了11例病例（平均年龄75岁），其中7例为女性。除2例病例外，所有病例均累及眼睑，肿瘤最大直径范围为6至25毫米。3例表现为派杰样扩散。在所有报告为切除不完全的肿瘤（4例）中均出现复发，其中只有1例表现为派杰样扩散。肿瘤大小不能预测复发情况。
在我们科室中，皮脂腺癌的最佳预后因素是组织学报告证实肿瘤已完全切除，无论肿瘤大小或所确定的扩散模式如何。
