Lorentzon Mattias, Mellström Dan, Ohlsson Claes
Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Gothenburg University, Gothenburg, Sweden.
J Bone Miner Res. 2005 Nov;20(11):1936-43. doi: 10.1359/JBMR.050709. Epub 2005 Jul 18.
In this population-based study, amount of PA was associated with cortical bone size (increased thickness and periosteal circumference) and trabecular vBMD, but not with cortical vBMD or length of the long bones in young men. The lowest effective amount of PA was > or = 4 h/week.
Physical activity (PA) is believed to have positive effects on the skeleton and possibly help in preventing the occurrence of osteoporosis. Neither the lowest effective amount of PA needed to induce an osteogenic response nor its effect on the BMD and size of the different bone compartments (i.e., trabecular and cortical bone) has yet been clarified.
In this population-based study, we investigated the amount of all types of PA in relation to areal BMD (aBMD), trabecular and cortical volumetric BMD (vBMD), and cortical bone size in 1068 men (age, 18.9 +/- 0.02 years), included in the Gothenburg Osteoporosis and Obesity Determinants (GOOD) study. aBMD was measured by DXA, whereas cortical and trabecular vBMD and bone size were measured by pQCT.
The amount of PA was associated with aBMD of the total body, radius, femoral neck, and lumbar spine, as well as with cortical bone size (increased thickness and periosteal circumference) and trabecular vBMD, but not with cortical vBMD or length of the long bones. The lowest effective amount of PA was > or = 4 h/week. aBMD, cortical bone size, and trabecular vBMD were higher in subjects who started their training before age 13 than in subjects who started their training later in life. Our data indicate that > or = 4 h/week of PA is required to increase bone mass in young men and that exercise before and during the pubertal growth is of importance. These findings suggest that PA is imperative for the augmentation of cortical bone size and trabecular vBMD but does not affect the cortical vBMD in young men.
在这项基于人群的研究中，体力活动量与皮质骨大小（厚度增加和骨膜周长增加）及小梁骨体积骨密度相关，但与年轻男性的皮质骨体积骨密度或长骨长度无关。体力活动的最低有效量为≥4小时/周。
体育活动（PA）被认为对骨骼有积极影响，并可能有助于预防骨质疏松症的发生。诱导成骨反应所需的PA最低有效量及其对不同骨区室（即小梁骨和皮质骨）的骨密度和大小的影响尚未明确。
在这项基于人群的研究中，我们调查了1068名男性（年龄18.9±0.02岁）参与哥德堡骨质疏松与肥胖决定因素（GOOD）研究中所有类型PA的量与面积骨密度（aBMD）、小梁骨和皮质骨体积骨密度（vBMD）以及皮质骨大小的关系。aBMD通过双能X线吸收法测量，而皮质骨和小梁骨vBMD及骨大小通过外周定量CT测量。
PA量与全身、桡骨、股骨颈和腰椎的aBMD相关，也与皮质骨大小（厚度增加和骨膜周长增加）及小梁骨vBMD相关，但与皮质骨vBMD或长骨长度无关。PA的最低有效量为≥4小时/周。13岁前开始训练的受试者的aBMD、皮质骨大小和小梁骨vBMD高于成年后开始训练的受试者。我们的数据表明，年轻男性增加骨量需要≥4小时/周的PA，青春期生长前和生长期间的运动很重要。这些发现表明，PA对于增加年轻男性的皮质骨大小和小梁骨vBMD至关重要，但不影响皮质骨vBMD。
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