Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
J Bone Miner Res. 2012 Oct;27(10):2198-207. doi: 10.1002/jbmr.1675.
The aim of this study was to investigate the development of bone mineral density (BMD) and bone mineral content (BMC) in relation to peak height velocity (PHV), and to investigate whether late normal puberty was associated with remaining low BMD and BMC in early adulthood in men. In total, 501 men (mean ± SD, 18.9 ± 0.5 years of age at baseline) were included in this 5-year longitudinal study. Areal BMD (aBMD) and BMC, volumetric BMD (vBMD) and cortical bone size were measured using dual-energy X-ray absorptiometry (DXA) and pQCT. Detailed growth and weight charts were used to calculate age at PHV, an objective assessment of pubertal timing. Age at PHV was a strong positive predictor of the increase in aBMD and BMC of the total body (R(2) aBMD 11.7%; BMC 4.3%), radius (R(2) aBMD 23.5%; BMC 22.3%), and lumbar spine (R(2) aBMD 11.9%; BMC 10.5%) between 19 and 24 years (p < 0.001). Subjects were divided into three groups according to age at PHV (early, middle, and late). Men with late puberty gained markedly more in aBMD and BMC at the total body, radius, and lumbar spine, and lost less at the femoral neck (p < 0.001) than men with early puberty. At age 24 years, no significant differences in aBMD or BMC of the lumbar spine, femoral neck, or total body were observed, whereas a deficit of 4.2% in radius aBMD, but not in BMC, was seen for men with late versus early puberty (p < 0.001). pQCT measurements of the radius at follow-up demonstrated no significant differences in bone size, whereas cortical and trabecular vBMD were 0.7% (p < 0.001) and 4.8% (p < 0.05) lower in men with late versus early puberty. In conclusion, our results demonstrate that late puberty in males was associated with a substantial catch up in aBMD and BMC in young adulthood, leaving no deficits of the lumbar spine, femoral neck, or total body at age 24 years.
本研究旨在探讨骨密度（BMD）和骨矿物质含量（BMC）的发育与峰值身高速度（PHV）的关系，并探讨男性青春期后期是否与成年早期的低骨密度和 BMC 有关。本研究共纳入 501 名男性（基线时年龄为 18.9 ± 0.5 岁），进行了为期 5 年的纵向研究。使用双能 X 射线吸收法（DXA）和 pQCT 测量骨面积密度（aBMD）和 BMC、体积密度（vBMD）和皮质骨大小。详细的生长和体重图表用于计算 PHV 的年龄，这是青春期时间的客观评估。PHV 的年龄是全身（aBMD 增加 11.7%；BMC 增加 4.3%）、桡骨（aBMD 增加 23.5%；BMC 增加 22.3%）和腰椎（aBMD 增加 11.9%；BMC 增加 10.5%）在 19 至 24 岁之间增加的强有力的正预测因子（p < 0.001）。根据 PHV 的年龄（早期、中期和晚期）将受试者分为三组。青春期后期的男性在全身、桡骨和腰椎的 aBMD 和 BMC 增加显著更多，而在股骨颈的减少更少（p < 0.001），而青春期早期的男性则不然。在 24 岁时，腰椎、股骨颈或全身的 aBMD 或 BMC 没有观察到显著差异，而与青春期早期相比，青春期后期的男性桡骨 aBMD 减少 4.2%，但 BMC 没有减少（p < 0.001）。随访时桡骨的 pQCT 测量显示骨大小无显著差异，而皮质和小梁 vBMD 分别低 0.7%（p < 0.001）和 4.8%（p < 0.05）在青春期后期男性。综上所述，我们的结果表明，男性青春期后期与成年早期的 aBMD 和 BMC 显著增加有关，在 24 岁时没有腰椎、股骨颈或全身的缺陷。
