儿科心脏病患者中抗生素与华法林的相互作用。

Interaction of antibiotics and warfarin in pediatric cardiology patients.

作者信息

Johnson M C, Wood M, Vaughn V, Cowan L, Sharkey A M

机构信息

Division of Pediatric Cardiology, Department of Pediatrics, Washington University School of Medicine/St. Louis Children's Hospital, 1 Children's Place, St. Louis, MO 63110, USA.

出版信息

Pediatr Cardiol. 2005 Sep-Oct;26(5):589-92. doi: 10.1007/s00246-005-0819-5.

DOI:10.1007/s00246-005-0819-5

PMID:16235009

Abstract

Antibiotics are known to alter the anticoagulation induced by warfarin in adults, but little is known about this interaction in children. In a retrospective review of patients under the age of 21 years, we found that antibiotic therapy (89 courses of antibiotics in 23 patients) was associated with an increase in the mean international normalized ratio (INR) from 2.7 to 3.6. The change in INR correlated inversely with patient age. These data suggest that more intensive monitoring of the INR after starting antibiotics may help to mitigate excessive anticoagulation in children receiving warfarin.

摘要

众所周知，抗生素会改变成人华法林诱导的抗凝作用，但对于儿童中的这种相互作用知之甚少。在一项对21岁以下患者的回顾性研究中，我们发现抗生素治疗（23名患者接受了89个疗程的抗生素治疗）使平均国际标准化比值（INR）从2.7升至3.6。INR的变化与患者年龄呈负相关。这些数据表明，开始使用抗生素后加强对INR的监测可能有助于减轻接受华法林治疗儿童的过度抗凝作用。