米氮平引起的关节痛。
Mirtazapine-induced arthralgia.
作者信息
Passier Anneke, van Puijenbroek Eugène
机构信息
Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5327 MH 's-Hertogenbosch, the Netherlands.
出版信息
Br J Clin Pharmacol. 2005 Nov;60(5):570-2. doi: 10.1111/j.1365-2125.2005.02481.x.
AIM
With this article, we intend to corroborate the assumed association between mirtazapine and arthralgia by presentation of eight case reports, and we describe a possible mechanism of action.
METHODS AND RESULTS
The Netherlands Pharmacovigilance Centre Lareb received eight case reports on arthralgia associated with use of mirtazapine. These case reports are presented in short. We also present worldwide data on this association.
CONCLUSIONS
The Lareb reports support the association between mirtazapine and arthralgia. A comparison is made between mirtazapine, mianserin and nefazodone, as these antidepressants show similarities in their mode of action and are all associated with arthralgia. We suggest that this adverse drug reaction may be induced by enhanced 5HT1-mediated neurotransmission.
目的
通过展示八例病例报告，我们旨在证实米氮平与关节痛之间假定的关联，并描述一种可能的作用机制。
方法与结果
荷兰药物警戒中心Lareb收到了八例与使用米氮平相关的关节痛病例报告。这些病例报告简要呈现。我们还展示了关于这种关联的全球数据。
结论
Lareb的报告支持米氮平与关节痛之间的关联。对米氮平、米安色林和奈法唑酮进行了比较，因为这些抗抑郁药在作用方式上有相似之处，且都与关节痛有关。我们认为这种药物不良反应可能是由5HT1介导的神经传递增强所致。
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