Jolliet P, Veyrac G, Bourin M
Laboratory of Pharmacology, University of Nantes, 1 rue Gaston Veil, 44035 Nantes cedex 1, France.
Eur Psychiatry. 2001 Dec;16(8):503-5. doi: 10.1016/s0924-9338(01)00614-9.
The aim of our work is to describe the first two cases of arthralgia associated with the antidepressant drug mirtazapine.
Descriptive analysis of two iatrogenic cases. The review of the literature was achieved by the traditional electronic methods. The French database of iatrogenic cases was consulted.
A 53-year-old man presented with gonalgia after some weeks of mirtazapine treatment. The intensity of the arthralgia was correlated with the dosage and the adverse effect rapidly disappeared after the antidepressant therapy was stopped. A 38-year-old woman received mirtazapine for 3 months and complained of arthralgia and myalgia. This clinical picture was suspended as the drug was stopped and a positive reintroduction was observed. No other cause was found in these two patients.
No similar case has been reported in the international literature, but several observations of arthralgia with mianserin are mentioned. As mirtazapine is the 6-aza derivative of the tetracyclic antidepressant mianserin, the similarities of their chemical structures begs the responsibility of mirtazapine for arthralgia.
我们的工作目的是描述与抗抑郁药物米氮平相关的前两例关节痛病例。
对两例医源性病例进行描述性分析。通过传统电子方法进行文献回顾。查阅了法国医源性病例数据库。
一名53岁男性在接受米氮平治疗数周后出现膝痛。关节痛的强度与剂量相关，在停用抗抑郁治疗后不良反应迅速消失。一名38岁女性接受米氮平治疗3个月，主诉关节痛和肌痛。随着药物停用，这种临床症状消失，再次用药时症状复发。这两名患者未发现其他病因。
国际文献中未报道过类似病例，但提到了几例与米安色林相关的关节痛观察病例。由于米氮平是四环抗抑郁药米安色林的6-氮杂衍生物，它们化学结构的相似性使人认为米氮平可能是导致关节痛的原因。
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