新型联芳基二肽基肽酶IV抑制剂的发现、构效关系及X射线结构
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.
作者信息
Qiao Lei, Baumann Christian A, Crysler Carl S, Ninan Nisha S, Abad Marta C, Spurlino John C, Desjarlais Renee L, Kervinen Jukka, Neeper Mike P, Bayoumy Shariff S, Williams Robyn, Deckman Ingrid C, Dasgupta Malini, Reed Rolanda L, Huebert Norman D, Tomczuk Bruce E, Moriarty Kevin J
机构信息
Johnson and Johnson Pharmaceutical Research and Development, 665 Stockton Drive, Exton, PA 19341, USA.
出版信息
Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. doi: 10.1016/j.bmcl.2005.09.037. Epub 2005 Oct 19.
The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.
新型联芳基氨基酰基-(S)-2-氰基吡咯烷和联芳基氨基酰基噻唑烷作为二肽基肽酶IV（DPP IV）强效抑制剂的发现、构效关系及X射线晶体结构已被报道。
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