Kar Moumita, Basak Amit, Bhattacharjee Manish
Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India.
Bioorg Med Chem Lett. 2005 Dec 15;15(24):5392-6. doi: 10.1016/j.bmcl.2005.09.005. Epub 2005 Oct 19.
Cyclic enediynes 1a and 2a containing stable E-azo moiety (azoenediynes) have been synthesized. These compounds upon irradiation with long wavelength UV isomerize to the Z-compounds 1b and 2b, which can be thermally reisomerized to the Z compounds. Reactivity studies toward BC using DSC predictably indicate higher reactivity for the Z-isomers. Our studies may provide a novel way to modulate the reactivity of enediynes under thermal or photochemical conditions.
