van Gaalen Floris, Ioan-Facsinay Andreea, Huizinga Tom W J, Toes René E M
Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands.
J Immunol. 2005 Nov 1;175(9):5575-80. doi: 10.4049/jimmunol.175.9.5575.
Rheumatoid arthritis is a chronic inflammatory autoimmune disease of unknown cause. The immune response against citrullinated Ags has recently become the prime suspect for disease pathogenesis. Immunity against citrullinated Ags is thought to play a pivotal role in the disease for several reasons: 1) citrullinated Ags are expressed in the target organ, the inflamed joint; 2) anti-citrullinated protein Abs are present before the disease becomes manifest; and 3) these Abs are highly specific for rheumatoid arthritis. In this review, data from clinical, genetic, biochemical, and animal studies is combined to create a profile of this remarkable autoantibody response. Moreover, a model is proposed of how the anti-citrullinated proteins response is generated and how it could eventually lead to chronic inflammation.
类风湿性关节炎是一种病因不明的慢性炎症性自身免疫性疾病。针对瓜氨酸化抗原的免疫反应最近已成为疾病发病机制的主要怀疑对象。针对瓜氨酸化抗原的免疫被认为在该疾病中起关键作用，原因如下：1）瓜氨酸化抗原在靶器官即发炎的关节中表达；2）抗瓜氨酸化蛋白抗体在疾病显现之前就已存在；3）这些抗体对类风湿性关节炎具有高度特异性。在本综述中，结合了临床、遗传、生化和动物研究的数据，以勾勒出这种显著的自身抗体反应的概况。此外，还提出了一个模型，说明抗瓜氨酸化蛋白反应是如何产生的，以及它最终如何导致慢性炎症。
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