Bautista-Molano Wilson, van der Heijde Desirée, Landewé Robert, Lafaurie Gloria I, de Ávila Juliette, Valle-Oñate Rafael, Romero-Sanchez Consuelo
Rheumatology Department, Leiden University Medical Center, Leiden, The Netherlands.
Rheumatology Department, School of Medicine, Universidad Militar Nueva Granada and Hospital Militar, Bogota, Colombia.
RMD Open. 2017 Dec 10;3(2):e000547. doi: 10.1136/rmdopen-2017-000547. eCollection 2017.
To compare the frequency and severity of periodontitis in patients with spondyloarthritis (SpA) with healthy control individuals, through the evaluation of clinical, serological and microbiological periodontal condition.
Patients with a diagnosis of SpA (n=78) and biological disease-modifying antirheumatic drug (bDMARD) naive fulfilling the Assessment of SpondyloArthritis international Society (ASAS) classification criteria as well as 156 healthy controls matched for age/gender were included. Two trained and calibrated periodontologists performed the periodontal clinical assessment. The presence of periodontitis and its severity were determined according to the criteria established by the Centers for Disease Control and Prevention-American Academy of Periodontology. The clinical periodontal variables, IgG1/IgG2 antibodies against periodontopathic bacterial identification, were also established. Comparisons of periodontal characteristics between the patients with SpA and the control group were performed using univariable analyses. A logistic regression analyses was performed to calculate the OR (95% CI) for diagnosis of periodontitis in patients with SpA and matched controls.
A diagnosis of periodontitis was established in 56% in patients with SpA versus 69% of healthy controls (P≤ 0.01). Severe periodontitis was found in 3% versus 12% in SpA versus healthy controls, respectively (P≤ 0.01). There was no significant increase of frequency of any periodontal variable, IgG1/IgG2 antibodies against or the presence of periodontopathic bacteria between patients with SpA and control group. Periodontitis was not positively associated with a diagnosis of SpA (OR: 0.57, 95% CI 0.32 to 1.00, P=0.05) in the logistic regression analyses.
We found a lower rather than a higher frequency and severity of periodontitis in patients with SpA in comparison with healthy control individuals. Our findings suggest that there is no positive association between SpA and periodontitis in Colombian patients.
通过评估临床、血清学和微生物学方面的牙周状况，比较脊柱关节炎（SpA）患者与健康对照者牙周炎的发生率和严重程度。
纳入诊断为SpA（n = 78）且未使用生物性改善病情抗风湿药物（bDMARD）并符合国际脊柱关节炎协会（ASAS）分类标准的患者，以及156名年龄/性别匹配的健康对照者。两名经过培训且校准过的牙周病医生进行牙周临床评估。根据美国疾病控制与预防中心-美国牙周病学会制定的标准确定牙周炎的存在及其严重程度。还确定了临床牙周变量、针对牙周病原菌鉴定的IgG1/IgG2抗体。使用单变量分析比较SpA患者与对照组之间的牙周特征。进行逻辑回归分析以计算SpA患者和匹配对照组中牙周炎诊断的OR（95%CI）。
SpA患者中56%被诊断为牙周炎，而健康对照者中这一比例为69%（P≤0.01）。SpA患者中重度牙周炎的比例为3%，而健康对照者中为12%（P≤0.01）。SpA患者与对照组之间在任何牙周变量的频率、针对牙周病原菌的IgG1/IgG2抗体或牙周病原菌的存在方面均无显著增加。在逻辑回归分析中，牙周炎与SpA的诊断无正相关（OR：0.57，95%CI 0.32至1.00，P = 0.05）。
我们发现与健康对照者相比，SpA患者的牙周炎发生率和严重程度较低而非较高。我们的研究结果表明，在哥伦比亚患者中，SpA与牙周炎之间无正相关。
