Segura M J, Gandolfo C N, Sica R E
Division Neurologia, Hosp. J.M. Ramos Mejia, Buenos Aires, Argentina.
Electromyogr Clin Neurophysiol. 1992 Jun;32(6):299-305.
Central Motor Conduction Time (CMCT) was assessed in 30 healthy volunteers and 22 patients with spinal cord lesions due to compressive, degenerative and demyelinating disease. To obtain the CMCT, electrical Transcranial Stimulation and Percutaneous Spinal Stimulation or F wave calculations were employed. Pyramidal Tract (PT) conduction was always abnormal in the clinically impaired corticospinal tracts of all the studied patients. This results correlated with the degree of muscle weakness specially in those having compressive lesions. Subclinical evidence of pyramidal damage was also observed in two patients with Multiple Sclerosis. As opposed to the other groups, patients with degenerative spinal disease, showed essentially symmetric abnormalities. An important overlap of CMCT slowness was seen among the three studied groups, suggesting that this isolated clue is not valuable enough for aetiological suspicion. Double muscle responses due to single TCS were obtained, during rest, in some patients from each group, but never in controls. This pathological feature, not reported by others, could represent the excitation of indirect corticospinal connections, partially responsible for the residual motor function after PT damage.
对30名健康志愿者和22名因压迫性、退行性和脱髓鞘疾病导致脊髓损伤的患者进行了中枢运动传导时间（CMCT）评估。为了获得CMCT，采用了经颅电刺激、经皮脊髓刺激或F波计算。在所有研究患者临床上受损的皮质脊髓束中，锥体束（PT）传导总是异常的。这一结果与肌肉无力程度相关，特别是在患有压迫性损伤的患者中。在两名多发性硬化症患者中也观察到锥体损伤的亚临床证据。与其他组不同，退行性脊柱疾病患者表现出基本对称的异常。在三个研究组中观察到CMCT减慢有重要重叠，这表明这一单独线索对于病因学怀疑的价值不够大。在休息期间，每组的一些患者通过单次经颅磁刺激（TCS）获得了双肌肉反应，但对照组从未出现过。这种其他研究未报道的病理特征可能代表间接皮质脊髓连接的兴奋，这部分地导致了PT损伤后残余运动功能。
