Lee Yujin S, Hwang Jaeuk, Kim Seog Ju, Sung Young Hoon, Kim Jihyun, Sim Minyoung E, Bae Soojeong C, Kim Minue J, Lyoo In Kyoon
Department of Psychiatry, Eunpyung Metropolitan Hospital, Seoul, Republic of Korea.
J Psychiatr Res. 2006 Sep;40(6):528-34. doi: 10.1016/j.jpsychires.2005.08.012. Epub 2005 Oct 18.
The purpose of the current study was to investigate alterations of regional cerebral blood flow (rCBF) in subjects with panic disorder.
Twenty-two subjects with panic disorder who were under psychotropic medications and 25 age and gender-matched healthy comparison subjects were assessed regarding the rCBF of using Tc-99m-hexamethyl propylenamino oxime single photon emission tomography (SPECT). Using statistical parametric mapping, the rCBF was compared between panic disorder and healthy comparison groups.
Decreased rCBF flow in right superior temporal lobe was observed in subjects with panic disorder (p<0.05 after correction for multiple comparisons). The rCBF in right superior temporal gyrus negatively correlated with the duration of illness, scores of panic disorder severity scale (PDSS), Hamilton anxiety rating scale (HARS) and Zung self-rating anxiety scale (Z-SAS).
We report that there is a decreased cerebral blood flow of temporal regions of the brain in panic disorder and that this decrease may, in part, reflect the clinical severity of panic disorder.
本研究旨在调查惊恐障碍患者的局部脑血流量（rCBF）变化。
对22名正在服用精神药物的惊恐障碍患者以及25名年龄和性别匹配的健康对照者，使用锝-99m-六甲基丙烯胺肟单光子发射断层扫描（SPECT）评估其rCBF。采用统计参数映射法，比较惊恐障碍组和健康对照组之间的rCBF。
惊恐障碍患者右侧颞上叶的rCBF血流减少（多重比较校正后p<0.05）。右侧颞上回的rCBF与病程、惊恐障碍严重程度量表（PDSS）评分、汉密尔顿焦虑量表（HARS）评分和zung自评焦虑量表（Z-SAS）呈负相关。
我们报告惊恐障碍患者大脑颞区脑血流量减少，这种减少可能部分反映了惊恐障碍的临床严重程度。
