Mancia Filippo, Shapiro Lawrence
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Cell. 2005 Oct 21;123(2):185-7. doi: 10.1016/j.cell.2005.10.004.
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.
呈现在一个细胞表面的Ephrin配体与其并列细胞表面的受体结合，常常导致细胞间排斥。在本期《细胞》杂志中，杰恩斯等人（2005年）表明，Ephrin配体可以被由Ephrin受体和一种ADAM金属蛋白酶组成的对面细胞上的复合物从其膜连接中蛋白水解释放出来。
